Below are some potential notable starts being made by drivers this weekend. Notable meaning they will be tied with a driver in number of starts made in that specific series, or the number of starts being made is a significant number that they are reaching in their specific race this weekend at Darlington Raceway. Rankings reflect the all-time starts list for that series.
(The image above each series is the driver I find having the most notable start this weekend)
*This will be updated after qualifying for each race if a driver does not make the race.

This weekend at Darlington Ryan Ellis will make his 180th career O’Reilly Series start which will tie him with 2022 O’Reilly Series Champion, Daniel Hemric, for 79th most all-time. Image credit: @youngsmtrsports X Page
O’Reilly Auto Parts Series Starts
Ryan Sieg: 425th start! Ranks 9th
Joey Gase: 325th start! Ranks 24th
Ryan Ellis: 189th start ties Daniel Hemric, ranks 79th
Sheldon Creed: 161st start ties Ward Burton, ranks 105th
Kyle Sieg: 139th start ties Noah Gragson, ranks 122nd
Blaine Perkins, Harrison Burton & Sammy Smith: 133rd start ties Austin Cindric, ranks 130th
Nick Sanchez: 55th start ties Kyle Petty, ranks 272nd
Daniel Dye: 50th start! Ranks 293rd
Corey Day: 36th start ties Jeremy Mayfield, ranks 347th

A week after winning his first career Cup race Ryan Preece will make his 250th career Cup start at Darlington this weekend. Image credit: @RFKracing X Page
Cup Series Starts
Denny Hamlin: 747th start ties Sterling Marlin, ranks 15th
Austin Dillon: 471st start ties Paul Menard, ranks 58th
Erik Jones: 352nd start ties Ned Jarrett, ranks 86th
Daniel Suarez: 350th start! Ranks 88th
Ty Dillon: 308th start ties Bobby Isaac, ranks 104th
Ross Chastain: 286th start ties Mike Skinner, ranks 110th
Ryan Preece: 250th start! Ranks 123rd
Chase Briscoe: 207th start ties Alan Kulwicki, ranks 145th
Cole Custer: 180th start ties Justin Haley, ranks 168th
Ty Gibbs: 150th start! Ranks 192nd